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Orthomolecular medicine is a form of complementary and alternative medicine with the goal to preventing and treating disease with nutrients, often in the form of dietary supplements.[1][2] The term "orthomolecular" was first coined in a 1967 letter[3] by Nobel Prize winner Linus Pauling and later elaborated on in a 1968 paper[4] on micronutrients and psychiatry to express the idea of "the right molecules in the right amounts" (ortho is Greek for right[5]). In this paper, Pauling indicated that the right molecules are "substances that are normally present in the human body". Orthomolecular medicine began with a particular focus upon mental illness, and orthomolecular psychiatry remains a major subdiscipline.[6] Proponents state that orthomolecular treatments are based on patients' personal biochemistries[7] and employ naturally-occurring or bioequivalent biomolecules, particularly nutrients such as vitamins, dietary minerals, proteins, antioxidants,[8] amino acids, lipotropes,[9] prohormones, dietary fiber, fatty acids and other similar substances.[10]
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